A new study published in today’s Journal of the American Medical Association (JAMA) concludes that breast cancer survivors in China who ate tofu, soy milk and fresh beans as part of a diet rich in soy protein had a lower risk of dying and less chance their cancer would return. Those who ate the most soy protein had a 29 percent lower risk of dying and a 32 percent lower rate of their breast cancer returning than those who had the lowest intake of soy. This is the largest study to examine the influence of soy intake on breast cancer survival and recurrence; it followed over 5000 women for about 4 years. The foods included in the study were tofu, soy milk and fresh soy beans, all common choices in Asian meals.
The researchers said the results eased previous concern that isoflavones might interfere with tamoxifen, a cancer drug designed to block estrogen. The study found higher soy food consumption was beneficial regardless of whether a patient was taking tamoxifen.
Soy foods are rich in isoflavones, which are estrogen-like compounds that occur naturally in plant foods. Soy isoflavones may compete with the body’s estrogen in binding to cell receptors, reducing the amount of estrogen in the body and hindering the ability of cancers to grow. The most common types of breast cancer depend on estrogen to grow.
Eating soy food that is the equivalent to 11 grams (0.39 ounces) of soy protein or 40 milligrams of soy isoflavone a day was enough to see a benefit. In the study, the women consumed an average of 47 milligrams a day of isoflavone compared with the average U.S. intake of 1 milligram to 6 milligrams a day. Other ingredients in soy foods including folate, protein, calcium or fiber may also be responsible for the survival benefits.
The U.S. Food and Drug Administration recommends people consume 25 grams of soy protein a day, which contains about 50 milligrams of isoflavone, as part of a diet low in saturated fat and cholesterol that may help reduce the risk of heart disease. One cup of fortified soy milk contains 10 grams of soy protein, or 43 milligrams of isoflavone, while a half cup of a firm soybean patty called tempeh contains 16 grams, or 53 milligrams of isoflavone. A half-cup of tofu or about 1.5 cups of edamame, a green vegetable, also each contain 10 grams of soy protein.
More studies are needed in larger numbers of people among more diverse populations to fully understand the effects of soy on breast cancer survivors. In the meantime, the researchers say “clinicians can advise their patients with breast cancer that soy foods are safe to eat and that these foods may offer some protective benefit for long-term health. Patients with breast cancer can be assured that enjoying a soy latte or indulging in a pad thai with tofu causes no harm and, when consumed in plentiful amounts, may reduce risk of disease recurrence.”
Here’s the link to the original article: http://jama.ama-assn.org/cgi/content/full/302/22/2437